A 57-year-old man with chronic gout is given a prescription for a uricosuric agent. He is cautioned to avoid aspirin, NSAIDs, and other drugs that are secreted into the proximal tubule. The mechanism of action of the anti-gout medication is most likely direct inhibition of:

A 57-year-old man with chronic gout is given a prescription for a uricosuric agent. He is cautioned to avoid aspirin, NSAIDs, and other drugs that are secreted into the proximal tubule. The mechanism of action of the anti-gout medication is most likely direct inhibition of:



A. Absorption of dietary purines
B. AMP deaminase
C. Microtubule polymerization
D. Organic anion transporter
E. Xanthine oxidase


Answer: D


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Biomechanics

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