HK is a 64-year-old man with a history of hypertension and gout who presents to the family practice clinic with complaint of 48 hours of acute pain in his right elbow. He has taken indomethacin without relief. He denies trauma, but admits to drinking "more than I should" on a trip to Atlantic City during the previous weekend. He has had 3 gout flares in the past year that were relieved by indomethacin. The diagnosis of gout has been previously confirmed by aspiration and crystal examination. Chart review shows that HK's renal function is within normal limits. To control the acute pain, the doctor prescribes an oral medication that acts by inhibiting ß-tubulin polymerization thus interfering with microtubule formation. The doctor cautions the patient not to take any other medication or herbal products without checking with doctor because the prescribed drug is a substrate of:
A. CYP2D6
B. CYP3A4
C. N-acetyltransferase
D. OATP1B1
E. UGT1A1
Answer: B
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Biomechanics
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